Self-assembly of paclitaxel derivative and fructose as a potent inducer of immunogenic cell death to enhance cancer immunotherapy

Self-assembly of paclitaxel derivative and fructose as a potent inducer of immunogenic cell death to enhance cancer immunotherapy

Immunotherapy shows promise for tumor control but is limited by low response rates. Paclitaxel (PTX) induces immunogenic cell death (ICD), yet conventional delivery systems face challenges like low drug loading and insufficient intracellular accumulation, reducing ICD efficacy. Small-molecule self-a...

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Bibliographic Details
Main Authors: Manzhen Li, Likang Lu, Yaoyao Guo, Jingxin Fu, Ziqi Zhang, Pengxin Li, Yifei Guo, Meihua Han, Xiangtao Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Paclitaxel derivative
Phenylboronic acid
Resiquimod
Self-assembly
ICD
Chemoimmunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425003539
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