Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan

Induction of more severe central sensitization in a medication overuse headache model mice through active ingestion of rizatriptan

Abstract Background Medication overuse headache (MOH) is a secondary headache disorder arising from excessive use of acute analgesics in patients with primary headache. Current animal models that predominantly employ passive drug administration fail to recapitulate the hallmark feature of voluntary...

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Main Authors: Zhenjie Ma, Chenhao Li, Wenhao Bai, Wei Xie, Mingjie Zhang, Han Xiao, Cancan Chen, Yang Li, Wenwen Zhang, Deqi Zhai, Yingyuan Liu, Dengfa Zhao, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:The Journal of Headache and Pain
Subjects:
Medication overuse headache
Calcitonin gene-related peptide
Rimegepant
Hierarchical clustering
Network analysis
Online Access:https://doi.org/10.1186/s10194-025-02066-4
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https://doi.org/10.1186/s10194-025-02066-4

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