IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty

IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty

Abstract Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse health and psychosocial outcomes. Self‐limited delayed puberty (DP) segregates predominantly in an autosomal dominant pattern, but the underlying genetic background is unknown. Using exome and candid...

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Main Authors: Sasha R Howard, Leonardo Guasti, Gerard Ruiz‐Babot, Alessandra Mancini, Alessia David, Helen L Storr, Lousie A Metherell, Michael JE Sternberg, Claudia P Cabrera, Helen R Warren, Michael R Barnes, Richard Quinton, Nicolas de Roux, Jacques Young, Anne Guiochon‐Mantel, Karoliina Wehkalampi, Valentina André, Yoav Gothilf, Anna Cariboni, Leo Dunkel
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
delayed puberty
GnRH
hypothalamic amenorrhea
neuronal migration
puberty
Online Access:https://doi.org/10.15252/emmm.201606250
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https://doi.org/10.15252/emmm.201606250

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