Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models

Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models

Abstract Polygenic risk scores (PRSs) for several psychiatric disorders have been associated with the clinical presentation of bipolar disorder (BD). PRSs have also been suggested to moderate the associations between childhood maltreatment and BD severity. In this study, we investigated how PRSs for...

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Main Authors: Bruno Etain, Mohamed Lajnef, Ophélia Godin, Cynthia Marie-Claire, Frank Bellivier, Elisa Courtois, Violaine Latapie, Sébastien Gard, Raoul Belzeaux, Philippe Courtet, Caroline Dubertret, Emmanuel Haffen, Antoine Lefrere, Emilie Olie, Mircea Polosan, Paul Roux, Ludovic Samalin, Raymund Schwan, Marion Leboyer, Stéphane Jamain, on behalf of FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03466-5
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https://doi.org/10.1038/s41398-025-03466-5

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