Enantio- and Chemo-Selective HPLC Analysis of Silodosin on an Amylose-Based Chiral Stationary Phase

Enantio- and Chemo-Selective HPLC Analysis of Silodosin on an Amylose-Based Chiral Stationary Phase

A direct enantio- and chemo-selective high-performance liquid chromatographic method was developed for determining the enantiomeric impurity of the chiral active pharmaceutical ingredient silodosin. The simultaneous separation of enantiomers of silodosin and its main organic related substances liste...

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Bibliographic Details
Main Authors: Daniele Sadutto, Francesca Romana Mammone, Giulia D’Ettorre, Leo Zanitti, Daniela De Orsi, Romina Alfonsi, Francesca Prestinaci, Roberto Cirilli
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
silodosin
impurities
enantiomer
Japanese Pharmacopoeia
enantioselective HPLC
method validation
Online Access:https://www.mdpi.com/1420-3049/30/9/1966
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