Phosphorylated neurofilament heavy chain (pNfH) concentration in cerebrospinal fluid predicts overall disease aggressiveness (D50) in amyotrophic lateral sclerosis

Phosphorylated neurofilament heavy chain (pNfH) concentration in cerebrospinal fluid predicts overall disease aggressiveness (D50) in amyotrophic lateral sclerosis

IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by tremendous clinical heterogeneity that necessitates reliable biomarkers for the trajectory of the disease. The potential of phosphorylated Neurofilament-Heavy-chain (pNfH) measured in cerebr...

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Bibliographic Details
Main Authors: Julia Meyer, Nayana Gaur, Janina von der Gablentz, Bernd Friedrich, Annekathrin Roediger, Julian Grosskreutz, Robert Steinbach
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
neurofilament
disease aggressiveness
D50 model
ALS
progression rate
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1536818/full
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https://www.frontiersin.org/articles/10.3389/fnins.2025.1536818/full

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