Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease

Abstract Studies of the genetics of Alzheimer’s disease (AD) have largely focused on single nucleotide variants and short insertions/deletions. However, most of the disease heritability has yet to be uncovered, suggesting that there is substantial genetic risk conferred by other forms of genetic var...

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Bibliographic Details
Main Authors: Michael H. Guo, Wan-Ping Lee, Badri Vardarajan, Gerard D. Schellenberg, Jennifer E. Phillips-Cremins
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56400-0
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