Pathogenesis of Graves’ Disease Determined Using Single-Cell Sequencing with Thyroid Autoantigen Peptide Stimulation in B Cells

Pathogenesis of Graves’ Disease Determined Using Single-Cell Sequencing with Thyroid Autoantigen Peptide Stimulation in B Cells

This study reports the use of single-cell RNA sequencing to evaluate B cells in the peripheral blood mononuclear cells (PBMCs) and intrathyroidal blood mononuclear cells of patients with Graves’ disease (GD) undergoing thyroidectomy. These cells were stimulated with overlapping peptides of thyroid a...

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Bibliographic Details
Main Authors: Genki Kobayashi, Takuro Okamura, Yoshitaka Hashimoto, Kimiko Sakai, Madoka Sumi, Dan Imai, Nobuko Kitagawa, Masahide Hamaguchi, Michiaki Fukui
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
single-cell RNA sequencing
Graves’ disease
B cells
thyroid autoantigens
peptide stimulation
autoantibody production
Online Access:https://www.mdpi.com/2073-4409/14/14/1102
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https://www.mdpi.com/2073-4409/14/14/1102

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