Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis

Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis

Abstract Background Cystinosis is a rare, incurable lysosomal storage disease caused by mutations in the CTNS gene encoding the cystine transporter cystinosin, which leads to lysosomal cystine accumulation in all cells of the body. Patients with cystinosis display signs of podocyte damage characteri...

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Bibliographic Details
Main Authors: Sante Princiero Berlingerio, Tjessa Bondue, Sarah Tassinari, Florian Siegerist, Angela Ferrulli, Celien Lismont, Sara Cairoli, Bianca Maria Goffredo, Bart Ghesquière, Marc Fransen, Nicole Endlich, Fanny Oliveira Arcolino, Benedetta Bussolati, Lambertus van den Heuvel, Elena Levtchenko
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Cystinosis
Podocyte
Mitochondrial oxidative stress
Lipid peroxidation
Ferroptosis
ctns −/− [Tg(fabp10a:gc-EGFP)] zebrafish larvae model
Online Access:https://doi.org/10.1186/s12967-024-05996-w
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https://doi.org/10.1186/s12967-024-05996-w

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