Development and application of solid phase microextraction tips (SPME LC tips) method for therapeutic drug monitoring of gefitinib by LC-MS/MS

Development and application of solid phase microextraction tips (SPME LC tips) method for therapeutic drug monitoring of gefitinib by LC-MS/MS

Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer (NSCLC). Among the existing therapies for NSCLC, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can be mentioned. Gefitinib is one of the first-generation reversible EGFR-TKIs and its main...

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Bibliographic Details
Main Authors: Leonardo Costalonga Rodrigues, Lílian de Araújo Lima, Débora Zorrón Berlinck, Mariana Vieira Morau, Mauricio Wesley Perroud Junior, Patrícia Moriel, Jose Luiz Costa
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Green Analytical Chemistry
Subjects:
Solid phase microextraction tips
Gefitinib
Plasma
Therapeutic drug monitoring
Green analytical toxicology
LC-MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S2772577424000867
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