The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors

The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors

BackgroundMultiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, the primary resid...

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Main Authors: Patrick Vermersch, Laura Airas, Thomas Berger, Florian Deisenhammer, Nikolaos Grigoriadis, Hans-Peter Hartung, Melinda Magyari, Veronica Popescu, Carlo Pozzilli, Maura Pugliatti, Bart Van Wijmeersch, Magd Zakaria, Celia Oreja-Guevara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
central nervous system
disease management
microglia
multiple sclerosis
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1495529/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1495529/full

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