Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population
Purpose. The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. Methods. We included into the study 91 healthy volunteers between the ages of 20 and 77 years. We analyzed meibomian gland morph...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/7526120 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558199387979776 |
|---|---|
| author | Anna Machalińska Aleksandra Zakrzewska Krzysztof Safranow Barbara Wiszniewska Bogusław Machaliński |
| author_facet | Anna Machalińska Aleksandra Zakrzewska Krzysztof Safranow Barbara Wiszniewska Bogusław Machaliński |
| author_sort | Anna Machalińska |
| collection | DOAJ |
| description | Purpose. The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. Methods. We included into the study 91 healthy volunteers between the ages of 20 and 77 years. We analyzed meibomian gland morphology, function, and lid margin alterations. We correlated our findings with self-reported ocular symptoms, systemic medical history, lifestyle factors, and tear film abnormalities. Results. We observed that a high ocular surface disease index, a history of either chalazion or hordeolum, experience of puffy eyelids upon waking, and foreign body sensation all appeared to be predictors of an abnormal meiboscore after adjusting for age and sex (p=0.0007; p=0.001; p=0.02; p=0.001, resp.). Multivariate logistic regression model including age and sex showed that there were three independent predictors of abnormal meiboscore: older age (OR = 1.03, 95% CI = 1.01–1.04 per year, p=0.006), postmenopausal hormone therapy (OR = 4.98, 95% CI = 1.52–16.30, p=0.007), and the use of antiallergy drugs (OR = 5.85, 95% CI = 2.18–15.72, p=0.0004). Conclusion. Our findings extend current knowledge on the pathophysiology of MGL. |
| format | Article |
| id | doaj-art-b821a5181a6a4cf4b6f3d2baf62a46dd |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b821a5181a6a4cf4b6f3d2baf62a46dd2025-02-03T01:33:02ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/75261207526120Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy PopulationAnna Machalińska0Aleksandra Zakrzewska1Krzysztof Safranow2Barbara Wiszniewska3Bogusław Machaliński4Department of Histology and Embryology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, PolandDepartment of Histology and Embryology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, PolandDepartment of Histology and Embryology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, PolandPurpose. The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. Methods. We included into the study 91 healthy volunteers between the ages of 20 and 77 years. We analyzed meibomian gland morphology, function, and lid margin alterations. We correlated our findings with self-reported ocular symptoms, systemic medical history, lifestyle factors, and tear film abnormalities. Results. We observed that a high ocular surface disease index, a history of either chalazion or hordeolum, experience of puffy eyelids upon waking, and foreign body sensation all appeared to be predictors of an abnormal meiboscore after adjusting for age and sex (p=0.0007; p=0.001; p=0.02; p=0.001, resp.). Multivariate logistic regression model including age and sex showed that there were three independent predictors of abnormal meiboscore: older age (OR = 1.03, 95% CI = 1.01–1.04 per year, p=0.006), postmenopausal hormone therapy (OR = 4.98, 95% CI = 1.52–16.30, p=0.007), and the use of antiallergy drugs (OR = 5.85, 95% CI = 2.18–15.72, p=0.0004). Conclusion. Our findings extend current knowledge on the pathophysiology of MGL.http://dx.doi.org/10.1155/2016/7526120 |
| spellingShingle | Anna Machalińska Aleksandra Zakrzewska Krzysztof Safranow Barbara Wiszniewska Bogusław Machaliński Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population Journal of Ophthalmology |
| title | Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population |
| title_full | Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population |
| title_fullStr | Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population |
| title_full_unstemmed | Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population |
| title_short | Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population |
| title_sort | risk factors and symptoms of meibomian gland loss in a healthy population |
| url | http://dx.doi.org/10.1155/2016/7526120 |
| work_keys_str_mv | AT annamachalinska riskfactorsandsymptomsofmeibomianglandlossinahealthypopulation AT aleksandrazakrzewska riskfactorsandsymptomsofmeibomianglandlossinahealthypopulation AT krzysztofsafranow riskfactorsandsymptomsofmeibomianglandlossinahealthypopulation AT barbarawiszniewska riskfactorsandsymptomsofmeibomianglandlossinahealthypopulation AT bogusławmachalinski riskfactorsandsymptomsofmeibomianglandlossinahealthypopulation |