GPR35 prevents osmotic stress induced cell damage
Abstract GPR35 is an orphan G-protein coupled receptor that has been implicated in the development of cancer. GPR35 regulates the Na+/K+-ATPase’s pump and signalling function. Here we show GPR35’s critical role in ion flux that in turn controls cellular osmotic pressure and Na+-dependent transport i...
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| Main Authors: | Joshua E. Elias, Mekdes Debela, Gavin W. Sewell, Richard J. Stopforth, Hannah Partl, Sophie Heissbauer, Lorraine M. Holland, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07848-9 |
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