GPR35 prevents osmotic stress induced cell damage

Abstract GPR35 is an orphan G-protein coupled receptor that has been implicated in the development of cancer. GPR35 regulates the Na+/K+-ATPase’s pump and signalling function. Here we show GPR35’s critical role in ion flux that in turn controls cellular osmotic pressure and Na+-dependent transport i...

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Bibliographic Details
Main Authors: Joshua E. Elias, Mekdes Debela, Gavin W. Sewell, Richard J. Stopforth, Hannah Partl, Sophie Heissbauer, Lorraine M. Holland, Tom H. Karlsen, Arthur Kaser, Nicole C. Kaneider
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07848-9
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