Atorvastatin exhibits anticancer effects by inhibiting YAP/TAZ activity in mesenchymal-like non-small cell lung cancer

Atorvastatin exhibits anticancer effects by inhibiting YAP/TAZ activity in mesenchymal-like non-small cell lung cancer

Abstract Non-small cell lung cancer (NSCLC) accounts for most lung cancer diagnoses. Statins preferentially inhibit the proliferation of mesenchymal- over epithelial-like cells in various types of cancer, including NSCLCs. However, the mechanisms underlying the differential statin sensitivity of mes...

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Bibliographic Details
Main Authors: Takuro Ishikawa, Tomohito Okubo, Natsuki Matsushita, Jiro Tashiro, Katsuhiko Warita, Munekazu Naito
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Statins
Non-small cell lung cancer
YAP
TAZ
Mesenchymal cancer cells
Online Access:https://doi.org/10.1038/s41598-025-15624-2
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https://doi.org/10.1038/s41598-025-15624-2

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