Emergence and characterization of IncFII/IncR plasmids with multiple 5,692 bp- blaKPC−2-bearing tandem repeats in ceftazidime/avibactam non-susceptible Klebsiella pneumoniae strains

Emergence and characterization of IncFII/IncR plasmids with multiple 5,692 bp- blaKPC−2-bearing tandem repeats in ceftazidime/avibactam non-susceptible Klebsiella pneumoniae strains

Ceftazidime/avibactam (CAZ/AVI) is widely recognized as an effective treatment for infections caused by KPC-producing Klebsiella pneumoniae (KPC-Kp). However, the prevalence of CAZ/AVI resistance among KPC-Kp isolates has increased rapidly in recent years. In this study, high-level carbapenem resist...

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Main Authors: Hongmao Liu, Mei Zhu, Junwan Lu, Shan Wu, Rujian Ye, Wei Pan, Yirong Li, Qiyu Bao, Dawei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
Klebsiella pneumoniae
Ceftazidime/avibactam
blaKPC-2
hypervirulent
5,692 bp-tandem repeat
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1534631/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1534631/full

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