Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from LDHC in lung adenocarcinoma

Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from LDHC in lung adenocarcinoma

BackgroundLactate dehydrogenase C (LDHC) is a kind of cancer-testis antigen (CTA) that has been reported to be a biomarker for diagnosis, efficacy evaluation, and recurrence monitoring of lung adenocarcinoma (LUAD). This study aims to assess the value of LDHC in peptide-based vaccines for LUAD immun...

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Main Authors: Ruifang Zhong, Xiaohong Guo, Chuncai Wu, Yangyi Guo, Yanli Kang, Jianbin You, Falin Chen, Qianshun Chen, Liangyuan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma
HLA-A2
lactate dehydrogenase C
recombinant protein
peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564731/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564731/full

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