Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs

Escalating doses of intravenous APAC demonstrate antithrombotic effect in pigs

Abstract Background Locally acting antiplatelet and anticoagulant (APAC) is developed as an antithrombotic agent for administration during vascular interventions and in thrombo-inflammatory conditions. APAC has entered human studies as a dual inhibitor of von Willebrand factor-mediated platelet recr...

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Main Authors: Zsuzsa Bagoly, Annukka Jouppila, Rita Orbán-Kálmándi, Linda Lóczi, Dóra Bomberák, Zsófia Anna Kádár, Ádám Deák, Ádám Mátrai, Ildikó Beke Debreceni, János Kappelmayer, Norbert Németh, Riitta Lassila
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Thrombosis Journal
Subjects:
Coagulation
Platelets
Pharmacodynamics
Drug development
Online Access:https://doi.org/10.1186/s12959-025-00742-8
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https://doi.org/10.1186/s12959-025-00742-8

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