A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma
Background. To describe an extensive untreatable choroidal metastasis by retinoblastoma in the treated patient which was clinically indistinguishable from regular tumor recurrence. Methods. A 24-month-old girl without a family history of retinoblastoma (RB) was discovered to have group C RB in her r...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/6678779 |
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| author | Babak Masoomian Maria Pefkianaki Fariba Ghassemi Hamid Riazi-Esfahani |
| author_facet | Babak Masoomian Maria Pefkianaki Fariba Ghassemi Hamid Riazi-Esfahani |
| author_sort | Babak Masoomian |
| collection | DOAJ |
| description | Background. To describe an extensive untreatable choroidal metastasis by retinoblastoma in the treated patient which was clinically indistinguishable from regular tumor recurrence. Methods. A 24-month-old girl without a family history of retinoblastoma (RB) was discovered to have group C RB in her right eye and group D in her left eye. The patient received 12 cycles of intravenous chemotherapy, intra-arterial chemotherapy (IAC), and intravitreal chemotherapy for the left eye and focal adjuvant therapy (laser thermotherapy and cryotherapy) for both eyes. Six months after the last treatment, fundus examination showed a regressed tumor in both eyes. Ten months after the last treatment, except for in addition to tumor recurrence, rising intraocular pressure was noticed in the left eye. While doing IAC for the left eye, a very rapid growing yellowish dome-shaped mass was found which had doubled in size in two weeks. Enucleation was considered for her. Results. Pathology evaluation of the enucleated eye revealed a very massive dome-shaped choroidal metastasis invasion with poorly differentiated RB tumor. Prophylactic systemic chemotherapy was performed for the patient. Conclusion. Choroidal metastasis in RB patients is often diagnosed based on pathology reports, but it may rarely be seen in clinical examinations especially if the pattern of tumor recurrence and growth is abnormal. |
| format | Article |
| id | doaj-art-b7c6a27b88cd45169bc6e1f7c94088c3 |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-b7c6a27b88cd45169bc6e1f7c94088c32025-02-03T05:44:45ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302021-01-01202110.1155/2021/66787796678779A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated RetinoblastomaBabak Masoomian0Maria Pefkianaki1Fariba Ghassemi2Hamid Riazi-Esfahani3Ocular Oncology Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranOcular Oncology Service, OMMA Eye Center, Hygeia Hospital, Athens, GreeceOcular Oncology Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranOcular Oncology Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranBackground. To describe an extensive untreatable choroidal metastasis by retinoblastoma in the treated patient which was clinically indistinguishable from regular tumor recurrence. Methods. A 24-month-old girl without a family history of retinoblastoma (RB) was discovered to have group C RB in her right eye and group D in her left eye. The patient received 12 cycles of intravenous chemotherapy, intra-arterial chemotherapy (IAC), and intravitreal chemotherapy for the left eye and focal adjuvant therapy (laser thermotherapy and cryotherapy) for both eyes. Six months after the last treatment, fundus examination showed a regressed tumor in both eyes. Ten months after the last treatment, except for in addition to tumor recurrence, rising intraocular pressure was noticed in the left eye. While doing IAC for the left eye, a very rapid growing yellowish dome-shaped mass was found which had doubled in size in two weeks. Enucleation was considered for her. Results. Pathology evaluation of the enucleated eye revealed a very massive dome-shaped choroidal metastasis invasion with poorly differentiated RB tumor. Prophylactic systemic chemotherapy was performed for the patient. Conclusion. Choroidal metastasis in RB patients is often diagnosed based on pathology reports, but it may rarely be seen in clinical examinations especially if the pattern of tumor recurrence and growth is abnormal.http://dx.doi.org/10.1155/2021/6678779 |
| spellingShingle | Babak Masoomian Maria Pefkianaki Fariba Ghassemi Hamid Riazi-Esfahani A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma Case Reports in Ophthalmological Medicine |
| title | A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma |
| title_full | A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma |
| title_fullStr | A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma |
| title_full_unstemmed | A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma |
| title_short | A New Rapidly Growing Dome-Shaped Choroidal Lesion in an Eye with Treated Retinoblastoma |
| title_sort | new rapidly growing dome shaped choroidal lesion in an eye with treated retinoblastoma |
| url | http://dx.doi.org/10.1155/2021/6678779 |
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