Enhancing fibroblast–epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum–promoted colon cancer

Enhancing fibroblast–epithelial cell communications: Serpine2 as a key molecule in Fusobacterium nucleatum–promoted colon cancer

BackgroundFusobacterium nucleatum (Fn) has been identified as a causative factor in the progression of colon cancer. This study aims to integrate bulk RNA-seq with single-cell RNA-seq (scRNA-seq) to elucidate the molecular mechanisms by which Fn facilitates colon cancer progression.MethodsThe scRNA-...

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Bibliographic Details
Main Authors: Xueke Li, Simin Luo, Yifang Jiang, Qiong Ma, Fengming You, Qixuan Kuang, Xi Fu, Chuan Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
single cell RNA-seq
Fusobacterium nucleatum
colon cancer
SerpinE2
fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563922/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563922/full

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