Extensive natural variation in bacterial ribosomal drug-binding sites

Summary: Ribosomes from certain bacteria possess divergent drug-binding sites compared to those of Escherichia coli, leading to natural evasion or hypersensitivity to antibiotics. However, in the absence of systematic studies, it is unknown whether this divergence is rare or common among bacterial s...

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Bibliographic Details
Main Authors: Chinenye L. Ekemezie, Lewis I. Chan, Charlotte R. Brown, Karla Helena-Bueno, Tom A. Williams, Sergey V. Melnikov
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006497
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