Single-cell atlas of endothelial cells in atherosclerosis: identifying C1 CXCL12+ ECs as key proliferative drivers for immunological precision therapeutics in atherosclerosis

Single-cell atlas of endothelial cells in atherosclerosis: identifying C1 CXCL12+ ECs as key proliferative drivers for immunological precision therapeutics in atherosclerosis

BackgroundAtherosclerosis (AS) is a chronic inflammatory disease characterized by endothelial dysfunction, monocyte infiltration, smooth muscle proliferation, and extracellular matrix accumulation. Endothelial cell (EC) dysfunction plays a pivotal role in the initiation and progression of AS. Despit...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhenzhen Zhao, Yujiang Dong, Zhijie Zhao, Zhikai Xiahou, Cong Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	atherosclerosis single-cell RNA sequencing CXCL12 vascular remodeling inflammation cellular heterogeneity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569988/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The role of CXCL16 in atherosclerosis: from mechanisms to therapy
by: Yue Liu, et al.
Published: (2025-05-01)

Biomarker Significance of Serum CXCL8, CXCL10 and CXCL16 in Breast Tumors of Iraqi Patients
by: Aseel F Khalaf, et al.
Published: (2020-03-01)

Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair
by: Xingxiao Huang, et al.
Published: (2025-05-01)

Cellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosis
by: A. A. Sleptsov
Published: (2022-11-01)

Adipocyte-derived CXCL10 in obesity promotes the migration and invasion of ovarian cancer cells
by: Zhe Wang, et al.
Published: (2024-12-01)

CXCL10-dependent epithelial-vascular cross-talk for endothelial activation following SARS-CoV-2 infection
by: Chaillot Laura, et al.
Published: (2025-07-01)

REGULATION OF THE CXCL10 EXPRESSION AND INVESTIGATION OF THE RELATIONSHIPS OF THE CXCL10 DNA SEQUENCE VARIATION AND DISEASE
by: Hayriye Şentürk Çiftçi, et al.
Published: (2023-02-01)

The clinical significance of CXCL16 in the treatment of advanced non‐small cell lung cancer
by: Yuji Shibata, et al.
Published: (2020-05-01)

CXCL14 deficiency does not impact the outcome of influenza or Escherichia coli infections in mice
by: Abubaker ME Sidahmed, et al.
Published: (2014-10-01)

TELOMERE LENGTH AND ATHEROSCLEROSIS
by: O. M. Drapkina, et al.
Published: (2016-09-01)

CXCL8 is essential for cervical cancer cell acquired radioresistance and acts as a promising therapeutic target in cervical cancer
by: Qinghong Hu, et al.
Published: (2025-07-01)

The CXCL12/CXCR4 Axis: An Emerging Therapeutic Target for Chronic Pain
by: Chen Z, et al.
Published: (2025-05-01)

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma
by: Yulu Chen, et al.
Published: (2025-05-01)

CXCL2: a key player in the tumor microenvironment and inflammatory diseases
by: Yuanhao Lv, et al.
Published: (2025-04-01)

CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects
by: Lei Tang, et al.
Published: (2025-01-01)

Radiomics Signatures Based on Computed Tomography for Noninvasive Prediction of CXCL10 Expression and Prognosis in Ovarian Cancer
by: Xiaohua Wang, et al.
Published: (2024-10-01)

Single-cell RNA sequencing analysis reveals a lack of CXCL13+ T cell subsets associated with the recurrence of cervical squamous cell carcinoma following concurrent chemoradiotherapy
by: Xia Li, et al.
Published: (2025-06-01)

CXCL10-induced regulatory T cells and adenosine signaling promote immunosuppression and progression of epithelial ovarian cancer
by: Annabelle C. Lin, et al.
Published: (2025-07-01)

CXCL10 promotes melanoma angiogenesis and tumor growth
by: Bongjun Kim, et al.
Published: (2024-12-01)

CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals
by: Samuele Negro, et al.
Published: (2017-05-01)

Distinct inflammation-related proteins associated with T cell immune recovery during chronic HIV-1 infection
by: Lin-Yu Wan, et al.
Published: (2023-12-01)

Insufficient CXCL13 secretion in leprosy foamy macrophages attenuates lymphocyte recruitment and antimicrobial protein production
by: Chuan Wang, et al.
Published: (2025-04-01)

High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer
by: Shuning Xu, et al.
Published: (2025-05-01)

Inhibition of nitric oxide synthase activity and chemokine (CXCL12) supplementation can improve hematopoietic reconstitution in mice lethally irradiated by 60Co gamma radiation
by: Daniel Perez Vieira, et al.
Published: (2019-01-01)

Sex differences in CXCL4‐mediated lung damage in the bleomycin‐induced systemic sclerosis mice model
by: Yi'an Tian, et al.
Published: (2024-12-01)

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine
by: Sara Caxaria, et al.
Published: (2022-12-01)

CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival
by: Siyue Nie, et al.
Published: (2024-12-01)

Association of the SNPs in CCL2 and CXCL12 genes with the susceptibility to breast cancer: a case-control study in China
by: Duanchong Zhao, et al.
Published: (2024-12-01)

Curcumin inhibits ferroptosis-mediated vascular occlusion by regulating the CXCL10/CXCR3 axis in retinopathy of prematurity
by: Rui Niu, et al.
Published: (2025-03-01)

CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis
by: Xinyu Wang, et al.
Published: (2025-02-01)

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells
by: Hanchao Gao, et al.
Published: (2025-05-01)

Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses
by: Shi-Ze Leng, et al.
Published: (2024-12-01)

CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma
by: Shuyao Zhang, et al.
Published: (2025-07-01)

The Crosstalk with CXCL10‐Rich Tumor‐Associated Mast Cells Fuels Pancreatic Cancer Progression and Immune Escape
by: Hanlin Yin, et al.
Published: (2025-04-01)

Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU
by: Xin Hu, et al.
Published: (2025-02-01)

ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer
by: Hae-Yun Jung, et al.
Published: (2023-12-01)

The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma
by: Benjamin B. Gyau, et al.
Published: (2025-06-01)

PU.1 alleviates the inhibitory effects of cigarette smoke on endothelial progenitor cell function and lung-homing through Wnt/β-catenin and CXCL12/CXCR4 pathways
by: Xue He<sup>+</sup>, et al.
Published: (2024-01-01)

CXCL14 drives age-related intervertebral disc degeneration via NF-κB pathway activation in a multiomic study
by: Tianle Zhou, et al.
Published: (2025-07-01)

Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing
by: Seungchan An, et al.
Published: (2024-10-01)