Single-cell atlas of endothelial cells in atherosclerosis: identifying C1 CXCL12+ ECs as key proliferative drivers for immunological precision therapeutics in atherosclerosis

Single-cell atlas of endothelial cells in atherosclerosis: identifying C1 CXCL12+ ECs as key proliferative drivers for immunological precision therapeutics in atherosclerosis

BackgroundAtherosclerosis (AS) is a chronic inflammatory disease characterized by endothelial dysfunction, monocyte infiltration, smooth muscle proliferation, and extracellular matrix accumulation. Endothelial cell (EC) dysfunction plays a pivotal role in the initiation and progression of AS. Despit...

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Bibliographic Details
Main Authors: Zhenzhen Zhao, Yujiang Dong, Zhijie Zhao, Zhikai Xiahou, Cong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
single-cell RNA sequencing
CXCL12
vascular remodeling
inflammation
cellular heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569988/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569988/full

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