Afil, a Lectin from <i>Aplysina fistularis</i>, Exhibits Antibiofilm and Synergistic Antibacterial Activity Against Resistant Bacteria

Afil, a Lectin from <i>Aplysina fistularis</i>, Exhibits Antibiofilm and Synergistic Antibacterial Activity Against Resistant Bacteria

Lectins from marine sponges have emerged as promising candidates for antimicrobial strategies, particularly against biofilm-forming pathogens. In this study, we report the purification, biochemical characterization, and antibiofilm properties of a new lectin (AfiL) isolated from <i>Aplysina fi...

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Main Authors: Francisco Regivanio Nascimento Andrade, João Marcelo de Sousa Silva, Jéssica de Assis Duarte, Philippe Lima Duarte, Pedro Arthur Sousa Tabosa, Manoel Ferreira da Costa Filho, Juliana Sampaio Nogueira Marques, Alexandre Lopes Andrade, Renata Pinheiro Chaves, Mayron Alves de Vasconcelos, Elielton Nascimento, Ulisses Pinheiro, Edson Holanda Teixeira, Celso Shiniti Nagano, Alexandre Holanda Sampaio, Rômulo Farias Carneiro
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
marine sponge lectin
biofilm inhibition
antibiotic synergy
multidrug-resistant bacteria
lectin–carbohydrate interaction
Online Access:https://www.mdpi.com/2076-2607/13/6/1349
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