TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning

TRAF3 as a potential diagnostic biomarker for recurrent pregnancy loss: insights from single-cell transcriptomics and machine learning

Abstract Background Recurrent pregnancy loss (RPL), characterized by multiple miscarriages, remains a condition with unclear etiology, posing significant challenges for affected women and couples. This study aims to explore the underlying mechanisms of RPL, focusing on the role of decidual Natural K...

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Main Authors: Yi-bo He, Jun-yu Li, Shi-liang Chen, Rui Ye, Yi-ran Fei, Shi-yuan Tong, Yu-xuan Song, Cong Wang, Li Zhang, Ju Fang, Yue Shang, Zhe-zhong Zhang, Jin Chen, Ai-zhong Yang, Jie Liu, Yong-lin Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pregnancy and Childbirth
Subjects:
Recurrent Pregnancy Loss (RPL)
Decidual Natural Killer Cells (dNK)
Macrophage Migration Inhibitory Factor (MIF) pathway
Single-cell transcriptomics
High-Dimensional Weighted Gene Co-expression Network Analysis (HdWGCNA)
Machine learning
Online Access:https://doi.org/10.1186/s12884-025-07742-6
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https://doi.org/10.1186/s12884-025-07742-6

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