Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala

Loss of the zinc receptor ZnR/GPR39 in mice enhances anxiety-related behavior and motor deficits, and modulates KCC2 expression in the amygdala

Abstract Background Mood disorders, particularly depression and anxiety, are associated with zinc dyshomeostasis and aberrant GABAergic signaling. Activation of ZnR/GPR39 by synaptic zinc in the hippocampus triggers phosphorylation of extracellular regulated kinase (ERK1/2), which regulates the K+/C...

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Bibliographic Details
Main Authors: Romi Sagi, Moumita Chakraborty, Milos Bogdanovic, Hila Asraf, Israel Sekler, Ora Kofman, Hagit Cohen, Michal Hershfinkel
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Behavioral and Brain Functions
Subjects:
Zinc
ZnR/GPR39
Anxiety-related
KCC2
Motor coordination
Zinc signaling
Online Access:https://doi.org/10.1186/s12993-024-00254-x
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https://doi.org/10.1186/s12993-024-00254-x

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