Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity

Summary: Heterozygous mutations in any of the six H3K4 methyltransferases (KMT2s) result in monogenic neurodevelopmental disorders, indicating non-redundant yet poorly understood roles of this enzyme family in neurodevelopment. However, the specific cellular role of KMT2 enzymes in the brain remains...

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Bibliographic Details
Main Authors: Takao Tsukahara, Saini Kethireddy, Katherine M. Bonefas, Alex Chen, Brendan L.M. Sutton, Kenjiro Bandow, Yali Dou, Shigeki Iwase, Michael A. Sutton
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005170
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