Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery

Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology, proteolysis-targeting chimera (PROTAC), has revolutionized small-molecule drug discovery. However, PR...

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Bibliographic Details
Main Authors: Yu Ding, Dong Xing, Yiyan Fei, Shouqing Luo, Boxun Lu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Medicine Plus
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Online Access:http://www.sciencedirect.com/science/article/pii/S295034772300004X
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