Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease
Abstract Complement C1q initiates the classical complement pathway and becomes activated in Alzheimer’s disease (AD), contributing to the association between amyloid-β (Aβ) and tau pathologies. However, whether C1q influences AD pathology by modulating glial cell communication is unclear. We include...
Saved in:
| Main Authors: | Fan Guo, Ze-Hu Sheng, Yan Fu, Zhi-Bo Wang, Rong-Ji Xue, Lan Tan, Meng-Shan Tan, Zuo-Teng Wang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
|
| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-025-03458-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-05-01) -
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
by: Annerieke Sierksma, et al.
Published: (2020-01-01) -
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease
by: Nicolai Franzmeier, et al.
Published: (2025-03-01) -
Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
by: Abdolhossein Zare, et al.
Published: (2025-07-01) -
Diamagnetic Signature of Beta‐Amyloid (Aβ) and Tau (τ) Tangle Pathology in Alzheimer's Disease: A Review
by: Sadegh Ghaderi, et al.
Published: (2025-02-01)