Complement C1q is associated with neuroinflammation and mediates the association between amyloid-β and tau pathology in Alzheimer’s disease

Abstract Complement C1q initiates the classical complement pathway and becomes activated in Alzheimer’s disease (AD), contributing to the association between amyloid-β (Aβ) and tau pathologies. However, whether C1q influences AD pathology by modulating glial cell communication is unclear. We include...

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Bibliographic Details
Main Authors: Fan Guo, Ze-Hu Sheng, Yan Fu, Zhi-Bo Wang, Rong-Ji Xue, Lan Tan, Meng-Shan Tan, Zuo-Teng Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03458-5
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