Unravelling molecular mechanism of oral squamous cell carcinoma and genetic landscape: an insight into disease complexity, available therapies, and future considerations

Unravelling molecular mechanism of oral squamous cell carcinoma and genetic landscape: an insight into disease complexity, available therapies, and future considerations

Oral squamous cell carcinoma (OSCC) is a heterogeneous malignant neoplasm characterized by intricate molecular pathways and a varied genetic landscape, resulting in a diminished 5-year survival rate. Due to this complexity, many trials of emerging therapies are failing to improve the outcome and sur...

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Main Authors: Salima Shebbo, Nooralhuda Alateyah, Esraa Yassin, Doaa El Sayed Mahmoud, Faleh Tamimi, Lamyia Anweigi, Abdelbary Elhissi, Haissam Abou-Saleh, Mohamed A. Elrayess, Abdelali Agouni
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
oral squamous cell carcinoma (OSCC)
molecular pathways
genetic predisposition
immunotherapy
therapeutic challenges
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626243/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626243/full

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