Modal-nexus auto-encoder for multi-modality cellular data integration and imputation

Abstract Heterogeneous feature spaces and technical noise hinder the cellular data integration and imputation. The high cost of obtaining matched data across modalities further restricts analysis. Thus, there’s a critical need for deep learning approaches to effectively integrate and impute unpaired...

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Bibliographic Details
Main Authors: Zhenchao Tang, Guanxing Chen, Shouzhi Chen, Jianhua Yao, Linlin You, Calvin Yu-Chian Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53355-6
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