Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Abstract Background DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it is unclear whether DNAm alterations during certain d...

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Main Authors: Alexander Neumann, Sara Sammallahti, Marta Cosin-Tomas, Sarah E. Reese, Matthew Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrusaityte, Syed H. Arshad, Marian J. Bakermans-Kranenburg, Lawrence Beilin, Carrie Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, Celeste Eng, Brenda Eskenazi, Bernard F. Fuemmeler, Frank D. Gilliland, Regina Grazuleviciene, Siri E. Håberg, Gunda Herberth, Nina Holland, Amy Hough, Donglei Hu, Karen Huen, Anke Hüls, Marjo-Riitta Jarvelin, Jianping Jin, Jordi Julvez, Berthold V. Koletzko, Gerard H. Koppelman, Inger Kull, Xueling Lu, Léa Maitre, Dan Mason, Erik Melén, Simon K. Merid, Peter L. Molloy, Trevor A. Mori, Rosa H. Mulder, Christian M. Page, Rebecca C. Richmond, Stefan Röder, Jason P. Ross, Laura Schellhas, Sylvain Sebert, Dean Sheppard, Harold Snieder, Anne P. Starling, Dan J. Stein, Gwen Tindula, Marinus H. van IJzendoorn, Judith Vonk, Esther Walton, Jonathan Witonsky, Cheng-Jian Xu, Ivana V. Yang, Paul D. Yousefi, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Henning Tiemeier, Stephanie J. London, Janine F. Felix, Charlotte Cecil
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Medicine
Subjects:
Epigenetics
Pediatrics
Child psychiatry
DNA methylation
Longitudinal analysis
Meta-analysis
Online Access:https://doi.org/10.1186/s13073-025-01451-7
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https://doi.org/10.1186/s13073-025-01451-7

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