Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

Traffic-related ultrafine particles (UFPs) are an emerging health concern affecting the brain and increasing the risk of Alzheimer’s disease (AD). PI3K/AKT signaling is known to contribute to neuronal survival and to be altered in AD. The nasal olfactory mucosa (OM) is a sensory tissue exposed direc...

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Main Authors: Laura Mussalo, Alexey M. Afonin, Tana Zavodna, Zdenek Krejcik, Katerina Honkova, Claire Fayad, Muhammad Ali Shahbaz, Juho Kalapudas, Elina Penttilä, Heikki Löppönen, Anne M Koivisto, Tarja Malm, Jan Topinka, Pasi Jalava, Riikka Lampinen, Katja M. Kanninen
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Environment International
Subjects:
Olfactory mucosa (OM)
Ultrafine particle (UFP)
Alzheimer’s disease (AD)
MicroRNA (miRNA)
PI3K/AKT signaling
DNA methylation (DNAmet), integrative mRNA-miRNA-DNAmet analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025002351
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