Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis

Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis

Abstract In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving flap viability include angiogenesis promotion, oxidative stress inhibition, and cell death prevention. Recently, two-dimensional ultrathin Ti3C2TX...

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Main Authors: Ningning Yang, Rongrong Hua, Yingying Lai, Peijun Zhu, Jian Ding, Xianhui Ma, Gaoxiang Yu, Yiheng Xia, Chao Liang, Weiyang Gao, Zhouguang Wang, Hongyu Zhang, Liangliang Yang, Kailiang Zhou, Lu Ge
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
MXene
Oxidative stress
Pyroptosis
Angiogenesis
Ischaemic flap
Online Access:https://doi.org/10.1186/s12951-025-03343-9
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https://doi.org/10.1186/s12951-025-03343-9

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