A Novel Toolkit of SARS-CoV-2 Sub-Genomic Replicons for Efficient Antiviral Screening

A Novel Toolkit of SARS-CoV-2 Sub-Genomic Replicons for Efficient Antiviral Screening

SARS-CoV-2 is classified as a containment level 3 (CL3) pathogen, limiting research access and antiviral testing. To address this, we developed a non-infectious viral surrogate system using reverse genetics to generate sub-genomic replicons. These replicons contained the nsp1 mutations K164A and H16...

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Main Authors: Maximilian Erdmann, Peter A. C. Wing, Isobel Webb, Maia Kavanagh Williamson, Tuksin Jearanaiwitayakul, Edward Sullivan, James Bazire, Iart Luca Shytaj, Jane A. McKeating, David A. Matthews, Andrew D. Davidson
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Viruses
Subjects:
SARS-CoV-2
RNA replicon
antiviral
SARS-CoV-2 nsp1
Online Access:https://www.mdpi.com/1999-4915/17/5/597
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