Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain

Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain

Abstract Tripartite motif-containing protein 21 (TRIM21), and particularly its PRY-SPRY protein interaction domain, plays a critical role in the immune response by recognizing intracellular antibodies targeting them for degradation. In this study, we performed a crystallographic fragment screening (...

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Main Authors: Yeojin Kim, Aleksandar Lučić, Christopher Lenz, Frederic Farges, Martin P. Schwalm, Krishna Saxena, Thomas Hanke, Peter G. Marples, Jasmin C. Aschenbrenner, Daren Fearon, Frank von Delft, Andreas Krämer, Stefan Knapp
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01574-3
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https://doi.org/10.1038/s42004-025-01574-3

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