Efficacy of nitric oxide donors and EDTA against Pseudomonas aeruginosa biofilms: Implications for antimicrobial therapy in chronic wounds

Efficacy of nitric oxide donors and EDTA against Pseudomonas aeruginosa biofilms: Implications for antimicrobial therapy in chronic wounds

Opportunistic pathogen Pseudomonas aeruginosa plays a crucial role in chronic wound biofilms, increasing infection's morbidity and mortality. In recent years, the signalling molecule nitric oxide (NO) and chelating agent tetrasodium EDTA (T-EDTA) have been applied therapeutically owing to their...

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Bibliographic Details
Main Authors: Aaron Crowther, Gareth LuTheryn, Ramón Garcia-Maset, Maryam Parhizkar, J. Mark Sutton, Charlotte Hind, Dario Carugo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biofilm
Subjects:
Biofilm
Chronic wound
Pseudomonas aeruginosa
Nitric oxide
NONOate
EDTA
Online Access:http://www.sciencedirect.com/science/article/pii/S2590207525000280
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