Expedient access to bora-butenolide bioisosteres by counteranion-mediated trans-hydroboration of alkynes

Abstract The hydroboration of alkynes is a textbook example of a syn-selective concerted addition reaction, while trans-selective additions of borane to alkynes remain to be developed. We herein report a transition metal-free anti-addition of pinacolborane to alkynes, facilitated by the counteranion...

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Bibliographic Details
Main Authors: Yuan-Wen Liu, Yu Liu, Yanting Zheng, Mengfan Zhang, Meng-En Ren, Peiyu Hua, Jie Han, Alois Fürstner, Hongming Jin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60052-5
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