Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function

Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function

Background: TRPC5 proteins form plasma membrane cation channels and are expressed in the nervous and cardiovascular systems. TRPC5 activation leads to cell depolarization and increases neuronal excitability, whereas a homologous TRPC1 inhibits TRPC5 function via heteromerization. The mechanism under...

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Bibliographic Details
Main Authors: Isaac S. Demaree, Sanjay Kumar, Kayla Tennessen, Quyen Q. Hoang, Fletcher A. White, Alexander G. Obukhov
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
TRPC channels
cation channels
electrophysiology
molecular dynamics
TRPC1-TRPC5 heteromers
Online Access:https://www.mdpi.com/2073-4409/13/23/2019
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