Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing

Abstract Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments. Here, we demonstrate that with Oxford Nanopore Technologies (ONT) sequencing we can a...

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Main Authors: Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere
Format: Article
Language:English
Published: Springer Nature 2023-11-01
Series:EMBO Molecular Medicine
Subjects:
cancer
cell‐free DNA
fragmentomics
liquid biopsy
nanopore sequencing
Online Access:https://doi.org/10.15252/emmm.202217282
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https://doi.org/10.15252/emmm.202217282

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