Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions
Objective. The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers. The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC). Me...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/516395 |
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| _version_ | 1832562496136806400 |
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| author | Juan Xia Na Chen Yun Hong Xiaobing Chen Xiaoan Tao Bin Cheng Yulei Huang |
| author_facet | Juan Xia Na Chen Yun Hong Xiaobing Chen Xiaoan Tao Bin Cheng Yulei Huang |
| author_sort | Juan Xia |
| collection | DOAJ |
| description | Objective. The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers. The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC). Methods. In 13 normal oral epithelia, 24 dysplastic oral leukoplakia (OLK), and 40 OSCC specimens, expressions of CXCL12 and CXCR4 were evaluated by immunohistochemistry. Results. CXCR4 was expressed in 37.5% of OLK and 60% of OSCC. CXCL12 was detected in 50% of OLK and 62.5% of OSCC. In OLK, CXCR4 positive ratio showed no significant difference from normal epithelia, but the CXCL12 positive ratio was significantly higher. Significant relationship between CXCL12 and CXCR4 was found both in OLK and OSCC. Conclusion. Our results indicated that CXCL12/CXCR4 axis may play roles from early steps of oral malignant transformation and contribute to the progress of oral carcinogenesis. |
| format | Article |
| id | doaj-art-b679cc7ec3e745239371deec062804b1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b679cc7ec3e745239371deec062804b12025-02-03T01:22:34ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/516395516395Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant LesionsJuan Xia0Na Chen1Yun Hong2Xiaobing Chen3Xiaoan Tao4Bin Cheng5Yulei Huang6Department of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaDepartment of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, No. 56, Lingyuanxi Road, Guangdong, Guangzhou 510055, ChinaObjective. The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers. The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC). Methods. In 13 normal oral epithelia, 24 dysplastic oral leukoplakia (OLK), and 40 OSCC specimens, expressions of CXCL12 and CXCR4 were evaluated by immunohistochemistry. Results. CXCR4 was expressed in 37.5% of OLK and 60% of OSCC. CXCL12 was detected in 50% of OLK and 62.5% of OSCC. In OLK, CXCR4 positive ratio showed no significant difference from normal epithelia, but the CXCL12 positive ratio was significantly higher. Significant relationship between CXCL12 and CXCR4 was found both in OLK and OSCC. Conclusion. Our results indicated that CXCL12/CXCR4 axis may play roles from early steps of oral malignant transformation and contribute to the progress of oral carcinogenesis.http://dx.doi.org/10.1155/2012/516395 |
| spellingShingle | Juan Xia Na Chen Yun Hong Xiaobing Chen Xiaoan Tao Bin Cheng Yulei Huang Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions Mediators of Inflammation |
| title | Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions |
| title_full | Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions |
| title_fullStr | Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions |
| title_full_unstemmed | Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions |
| title_short | Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions |
| title_sort | expressions of cxcl12 cxcr4 in oral premalignant and malignant lesions |
| url | http://dx.doi.org/10.1155/2012/516395 |
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