The impact of ancestral, genetic, and environmental influences on germline de novo mutation rates and spectra

The impact of ancestral, genetic, and environmental influences on germline de novo mutation rates and spectra

Abstract De novo germline mutation is an important factor in the evolution of allelic diversity and disease predisposition in a population. Here, we study the influence of genetically-inferred ancestry and environmental factors on de novo mutation rates and spectra. Using a genetically diverse sampl...

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Main Authors: O. Isaac Garcia-Salinas, Seongwon Hwang, Qin Qin Huang, Rashesh Sanghvi, Daniel S. Malawsky, Joanna Kaplanis, Matthew D. C. Neville, Felix R. Day, Raheleh Rahbari, Aylwyn Scally, Hilary C. Martin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59750-x
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https://doi.org/10.1038/s41467-025-59750-x

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