The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-<span style="font-variant: small-caps">d</span>-Xylulose 5-Phosphate Reductoisomerase from <i>Plasmodium falciparum</i> Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying <i>N</i>-Substituents

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-<span style="font-variant: small-caps">d</span>-Xylulose 5-Phosphate Reductoisomerase from <i>Plasmodium falciparum</i> Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying <i>N</i>-Substituents

It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of <i>Plasmodium falciparum</i> by inhibiting 1-deoxy-<span style="font-variant: small-caps;">d</span>-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mev...

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Bibliographic Details
Main Authors: Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
crystal structure
DXR
fosmidomycin
IspC
malaria
Online Access:https://www.mdpi.com/1420-3049/30/1/72
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