Evolutionary insights into Interleukin-12 family targets across 405 species

Evolutionary insights into Interleukin-12 family targets across 405 species

The Interleukin-12 (IL-12) family ligand subunits (IL-12s) and receptor subunits (IL-12Rs) constitute pivotal regulators of immune homeostasis, with direct implications in autoimmune pathologies and oncogenesis. Through phylogenetic reconstruction, synteny analysis, and sequence alignment across 400...

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Bibliographic Details
Main Authors: Weibin Wang, Dawei Li, Kaiyong Luo, Baozheng Chen, Xuzhen Li, Tingting Hao, Dazhong Guo, Yang Dong, Ya Ning
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
interleukin-12
cytokine evolution
targeted therapy
cancer
Metazoa
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1584460/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1584460/full

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