Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants

Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants

Second-generation integrase strand transfer inhibitors (INSTIs) are strongly recommended for people living with HIV-1 (PLWH). The emergence of resistance to second-generation INSTIs has been infrequent and has not yet been a major issue in high-income countries. However, the delayed rollouts of thes...

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Bibliographic Details
Main Authors: Steven J. Smith, Xue Zhi Zhao, Stephen H. Hughes, Terrence R. Burke
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Viruses
Subjects:
integrase
resistance
potency
mutations
mutants
Online Access:https://www.mdpi.com/1999-4915/17/1/121
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