Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

Summary: The primary cilium plays a crucial function in sensing and transmitting extracellular signals into cells. The initiation of ciliogenesis hinges on the recruitment of Tau tubulin kinase 2 (TTBK2) to the distal appendages (DAs) of centrioles through CEP164. However, the detailed mechanism und...

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Main Authors: Po-Chun Chou, Yu-Hao Lin, I-Hsuan Lin, Tzu-Ying Lin, Yun-Chia Huang, Shi-Rong Hong, Ting-Jui Ben Chang, Yin Fang, Yizhi Lin, T. Tony Yang, Yu-Chun Lin, Jie-rong Huang, Won-Jing Wang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005819
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http://www.sciencedirect.com/science/article/pii/S2211124725005819

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