Pregnancy and the Biliary System
Alterations in the synthesis and secretion of bile salts and cholesterol and in gallbladder function occur during pregnancy. These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone al...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/582650 |
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| Summary: | Alterations in the synthesis and secretion of bile salts and
cholesterol and in gallbladder function occur during pregnancy. These changes
are related to the effects of estrogen and progesterone. Biliary cholesterol saturation
and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone also
diminishes gallbladder contractility and emptying. Gallstones occur in 2.5 to
11% of pregnant women and are associated with cholecystitis in 0.008 to 0.1%
of pregnant women. Operative treatment should be deferred if possible until after
delivery; failing that, surgery is best done in the second trimester. Endoscopic
pap1llotomy may prove to be the best therapy for choledocholithiasis. |
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| ISSN: | 0835-7900 |