Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation

Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation

Abstract Pseudomonas aeruginosa employs N-acylated L-homoserine lactones (AHLs) as autoinducers (AIs) for quorum sensing, which in the end is responsible for biofilm and virulence factor production along with the development of antibiotic resistance in bacteria. Here, we designed and synthesized a l...

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Main Authors: Mohamed M. S. Hamoud, Amany M. Ghanim, Abdalla E. A. Hassan, Hanan A. Abdel-Fattah, Hisham A. Abbas, Noura M. Seleem, Hend Kothayer, Nermine A. Osman
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Chemistry
Online Access:https://doi.org/10.1186/s13065-025-01560-9
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https://doi.org/10.1186/s13065-025-01560-9

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