Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction
Many attempts have been proposed to evaluate the linkage between the oral–gut–liver axis and the mechanisms related to the diseases’ establishment. One of them is the oral microbiota translocation into the bloodstream, liver, and gut, promoting a host dysbiosis and triggering the presence of some me...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2024/3985731 |
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| author | Paulina Hernández-Ruiz Alma R. Escalona Montaño Luis M. Amezcua-Guerra Héctor González-Pacheco Elena Niccolai Amedeo Amedei María M. Aguirre-García |
| author_facet | Paulina Hernández-Ruiz Alma R. Escalona Montaño Luis M. Amezcua-Guerra Héctor González-Pacheco Elena Niccolai Amedeo Amedei María M. Aguirre-García |
| author_sort | Paulina Hernández-Ruiz |
| collection | DOAJ |
| description | Many attempts have been proposed to evaluate the linkage between the oral–gut–liver axis and the mechanisms related to the diseases’ establishment. One of them is the oral microbiota translocation into the bloodstream, liver, and gut, promoting a host dysbiosis and triggering the presence of some metabolites such as trimethylamine N-oxide (TMAO), known as a risk marker for cardiovascular disease, and especially the myocardial infarction (MI). In the present pilot study, the involvement of oral dysbiosis related to the presence of TMAO has been considered an independent component of the standard risk factors (SRs) in the development of MI, which has not been previously described in human cohorts. A positive and significant correlation of TMAO levels with Porphyromonas was identified; likewise, the increase of the genus Peptidiphaga in patients without SRs was observed. We determined that the presence of SRs does not influence the TMAO concentration in these patients. This report is the first study where the relationship between oral dysbiosis and TMAO is specified in the Mexican population. Our findings provide information on the possible contribution of the oral pathogens associated with gut dysbiosis in the development of MI, although further analysis should be performed. |
| format | Article |
| id | doaj-art-b615b7686ca34cf0a043b63239e270e4 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b615b7686ca34cf0a043b63239e270e42025-02-03T05:55:28ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/2024/3985731Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial InfarctionPaulina Hernández-Ruiz0Alma R. Escalona Montaño1Luis M. Amezcua-Guerra2Héctor González-Pacheco3Elena Niccolai4Amedeo Amedei5María M. Aguirre-García6Unidad de Investigación UNAM-INCUnidad de Investigación UNAM-INCDepartamento de InmunologíaUnidad de Cuidados CoronariosDepartment of Experimental and Clinical MedicineDepartment of Experimental and Clinical MedicineUnidad de Investigación UNAM-INCMany attempts have been proposed to evaluate the linkage between the oral–gut–liver axis and the mechanisms related to the diseases’ establishment. One of them is the oral microbiota translocation into the bloodstream, liver, and gut, promoting a host dysbiosis and triggering the presence of some metabolites such as trimethylamine N-oxide (TMAO), known as a risk marker for cardiovascular disease, and especially the myocardial infarction (MI). In the present pilot study, the involvement of oral dysbiosis related to the presence of TMAO has been considered an independent component of the standard risk factors (SRs) in the development of MI, which has not been previously described in human cohorts. A positive and significant correlation of TMAO levels with Porphyromonas was identified; likewise, the increase of the genus Peptidiphaga in patients without SRs was observed. We determined that the presence of SRs does not influence the TMAO concentration in these patients. This report is the first study where the relationship between oral dysbiosis and TMAO is specified in the Mexican population. Our findings provide information on the possible contribution of the oral pathogens associated with gut dysbiosis in the development of MI, although further analysis should be performed.http://dx.doi.org/10.1155/2024/3985731 |
| spellingShingle | Paulina Hernández-Ruiz Alma R. Escalona Montaño Luis M. Amezcua-Guerra Héctor González-Pacheco Elena Niccolai Amedeo Amedei María M. Aguirre-García Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction Mediators of Inflammation |
| title | Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction |
| title_full | Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction |
| title_fullStr | Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction |
| title_full_unstemmed | Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction |
| title_short | Potential Association of the Oral Microbiome with Trimethylamine N-Oxide Quantification in Mexican Patients with Myocardial Infarction |
| title_sort | potential association of the oral microbiome with trimethylamine n oxide quantification in mexican patients with myocardial infarction |
| url | http://dx.doi.org/10.1155/2024/3985731 |
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